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The last proposed system of RBC vasodilation during the existence of nitrite would be the reduction of nitrite to NO by Hb. Brooks first analyzed the nitrite Hb interaction in 1937 which do the job was afterwards extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to variety metHb and NO (Brooks, 1937;